Local Intersection Volume (LIV) Descriptors: 3D-QSAR Models for PGI2 Receptor Ligands
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چکیده
Prostaciclina I 2 inibe a agregação plaquetária pela interação com um receptor específico de membrana. Neste trabalho, desenvolvemos modelos de QSAR-3D para uma série de compostos heterocíclicos aromáticos usando como descritor o volume de interseção local. Os modelos obtidos podem ser aplicados no desenvolvimento de novos ligantes de receptor da PGI 2 com potencial atividade anti-agregante plaquetária.
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تاریخ انتشار 2002